The South African Stem Cell Institute (SASCI) was established by a handful of medical doctors who shared a keen interest in integrative medicine.

Throughout their careers, in general practice, these doctors noted how dependent patients had become on chronic pain medications which never addressed the source of the ailment. This led them to seek out a more integrative approach to their treatments with a specific interest in nutrition, hormone balance, cellular health and musculoskeletal ailments. These interests eventually led to Prolotherapy as well, which would become the gateway to regenerative medicine.

Through their continuous international training and ongoing research, it was only a matter of time before they would be introduced to stem cell therapy. The outcome-based research and results that were presented during the international training sessions they attended were overwhelming, focusing mainly on the use of adult stem cells and PRP in combination with Prolotherapy in orthopedic conditions. It was the obvious next step to incorporate stem cells into their treatment regime back in South Africa, and the South African Stem Cell Institute was born.